[1] LEVIN M. Pharmaceutical Process Scale-up∥ALAN ROYCE, COLLEEN RUJGGE, MARK MECDON, et al. Scale-up of the Compaction and Tableting Process. Basel:Taylor & Francis, 2006:371-470. [2] LEUENBERGER H, LANZ M. Pharmaceutical powder technology —From art to science: The challenge of the FDA’s Process Analytical Technology initiative. Adv Powder Technol,2005. 16(1):3-25. [3] SUN C C. Materials science tetrahedron--a useful tool for pharmaceutical research and development. J Pharm Sci, 2009, 98(5):1671-1687. [4] THO I, BAUER-BRANDL A. Quality by design (QbD) approaches for the compression step of tableting. Expert Opin Drug Deliv, 2011, 8(12):1631-1644. [5] RILLEY B S, LIX. Quality by design and process analytical technology for sterile products--where are we now? . AAPS PharmSciTech, 2011, 12(1):114-118. [6] SUN C C, HOU H, GAO P, et al. Development of a high drug load tablet formulation based on assessment of powder manufacturability: Moving towards quality by design. J Pharm Sci, 2009, 98(1):239-247. [7] WANG C G, FANG J G. Pharmaceutical powers flow properties characterization: Methods and applications. Chin J New Drugs(中国新药杂志),2013,22(7):809-813.[8] QIU Y H, CHEN Y S, G. Z. ZHANG GEOFF, et al. Developing Solid Oral Dosage Forms∥AMIDON GE, SECREAST PJ, MUDIE D. Particle, Powder, and Compact Characterization. San Diego: Academic Press, 2009:163-186. [9] SUN C, GEANT D J. Compaction properties of L-lysine salts. Pharm Res, 2001, 18(3):281-286. FENG Y, GRANT D J, SUN C C. Influence of crystal structure on the tableting properties of n-alkyl 4-hydroxybenzoate esters (parabens) . J Pharm Sci, 2007, 96(12):3324-3333. SUN C, GRANT D J. Influence of crystal structure on the tableting properties of sulfamerazinepolymorphs. Pharm Res, 2001, 18(3):274-280. BAG P P, CHEN M, SUN C C, et al. Direct correlation among crystal structure, mechanical behaviour and tabletability in a trimorphic molecular compound. Cryst Eng Comm,2012, 14(11):3865-3867. SUN C, GRANT D J. Influence of crystal shape on the tableting performance of L-lysine monohydrochloridedihydrate. J Pharm Sci,2001, 90(5):569-579. MIRZA S, MIROSHNYK I, HEINANMRK J, et al. Crystal morphology engineering of pharmaceutical solids: Tabletting performance enhancement. AAPS Pharm Sci Tech, 2009, 10(1):113-119. SUN C, GRANT D J. Effects of initial particle size on the tableting properties of L-lysine monohydrochloridedihydratepowder. Int J Pharm, 2001, 215(1-2):221-228. PATEL S, DAHIYA S, SUN C C, et al. Understanding size enlargement and hardening of granules on tabletability of unlubricated granules prepared by dry granulation. J Pharm Sci, 2011, 100(2):758-766. SUN C C. Mechanism of moisture induced variations in true density and compaction properties of microcrystalline cellulose. Int J Pharm, 2008, 346(1-2):93-101. SUN C, GRANT D J. Improved tableting properties of p-hydroxybenzoic acid by water of crystallization: A molecular insight. Pharm Res, 2004, 21(2):382-386. PATEL S, KAUSHAI A M, BANSAL A K. Compression physics in the formulation development of tablets. Crit Rev Ther Drug Carrier Syst, 2006, 23(1):1-65. SHI L, FENG Y, SUN C C. Massing in high shear wet granulation can simultaneously improve powder flow and deteriorate powder compaction: A double-edged sword. Eur J Pharm Sci, 2011, 43(1-2):50-56. WU S J, SUN C. Insensitivity of compaction properties of brittle granules to size enlargement by roller compaction. J Pharm Sci, 2007, 96(5):1445-1450. TYE C K, SUN C C, AMIDON G E. Evaluation of the effects of tableting speed on the relationships between compaction pressure, tablet tensile strength, and tablet solid fraction. J Pharm Sci, 2005, 94(3):465-472. HIESTAND E N. Mechanical properties of compacts and particles that control tableting success. J Pharm Sci, 1997, 86(9):985-990. SUN C C. Decoding powder tabletability: Roles of particle adhesion and plasticity. J Adhesion Sci Technol, 2011, 25(4-5):483-499. SUN C C. A material-sparing method for simultaneous determination of true density and powder compaction properties--aspartame as an example. Int J Pharm, 2006, 326(1-2):94-99. SUN C C. True density of microcrystalline cellulose. J Pharm Sci, 2005, 94(10):2132-2134. RYSHKEWITCH E. Compression strength of porous sintered alumina and zirconia. J Am Ceram Soc, 1953,36(2):65-68. MORISSETTE S L, ALMARSSON O, PETERSON M L, et al. High-throughput crystallization: Polymorphs, salts, co-crystals and solvates of pharmaceutical solids. Adv Drug Deliv Rev, 2004, 56(3):275-300. BRITTAIN H G. Cocrystal systems of pharmaceutical interest: 2010. Crystal Growth & Design, 2011, 12(2):1046-1054. SUN C C, HOU H. Improving mechanical properties of caffeine and methyl gallate crystals by cocrystallization. Crystal Growth & Design, 2008, 8(5):1575-1579. SUN C C, KIANG Y H. On the identification of slip planes in organic crystals based on attachment energy calculation. J Pharm Sci,2008, 97(8):3456-3461. CHOW S F, CHEN M, SHI L, et al. Simultaneously improving the mechanical properties, dissolution performance, and hygroscopicity of ibuprofen and flurbiprofen by cocrystallization with nicotinamide. Pharm Res, 2012, 29(7):1854-1865. QIU Y H, CHEN Y S, ZHANG G Z, et al. Developing Solid Oral Dosage Forms∥ZANNOU EA, LIP, TONG WQ. Product Lifecycle Management (LCM). San Diego: Academic Press, 2009:911-921. CHATTORAJ S, SHI L, SUN C C. Understanding the relationship between crystal structure, plasticity and compaction behaviour of theophylline, methyl gallate, and their 1∶1 co-crystal. Cryst Eng Comm, 2010, 12(8):2466-2472. SHI L, SUN C C. Transforming powder mechanical properties by core/shell structure: Compressible sand. J Pharm Sci, 2010, 99(11):4458-4462. PERUMALLA SR, SHI L, SUN C C. Ionized form of acetaminophen with improved compaction properties. Cryst Eng Comm, 2012, 14(7):2389-2390. SHI L, SUN C C. Overcoming poor tabletability of pharmaceutical crystals by surface modification. Pharm Res, 2011, 28(12):3248-3255.